The foremost aim of this study was to evaluate the effect of G6PD deficiency (to mimic G6PD A− variant; mild-moderate) on TGF-β/NADPH oxidases/ROS signaling and cell adhesion molecules (CAM) in human aortic endothelial cells (HAEC) and monocyte-endothelial adhesion. Here, G6PD is linked to hyperinsulinemic hypoglycemia, familial, 4.