Monocyte-derived dendritic cells (mDCs) possess the capacity to generate Treg from naive CD4+ T cells in CHC patients and their interaction with HCV-infected hepatocytes results in increased production of the Treg-attracting chemokines CCL17 and CCL22, which facilitate intrahepatic recruitment of Tregs [124,125]. This evidence concerns the gene CD4 and cryohydrocytosis.