NLRP3 and Cognitive impairment: Fecal microbial transplantation (FMT) from AD patients worsened the severity of the disease and increased levels of the NLRP3 in transgenic mice, while transplantation in WT mice did not elicit cognitive deficits but raised levels of intestinal NLRP3, supporting the hypothesis that intestinal inflammation is an active player, although not the driver, in disease pathogenesis [153].