Another link between microbiota and ALS was reported by Burberry et al., who showed that a microbial environment enriched in pro-inflammatory bacteria elicits an exaggerated systemic and neural inflammation in C9orf72 knockout mice, suggesting that C9orf72 is implicated in the modulation of inflammatory responses elicited by altered GM both in- and outside the CNS [368]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.