Eight AMD loci (category 3: “CFH”, “COL8A1”, “TNFRSF10A”, “CETP”, “CTRB2/CTRB1”, “C3”, “CNN2”, and “MMP9”) revealed gene expression regulation effects only in extraocular tissues while five of these harbor multiple genes which were assigned to different categories. This evidence concerns the gene C3 and age-related macular degeneration.