PTGS2 and cancer: The pro-angiogenic effects of the COX-2/mPGE-1 pathway can be inhibited by NSAIDs in human and animal cancer cells lines and rescued by adding exogenous PGE2, suggesting that COX-2 derived PGE2 is, at least in part, responsible for the pro-angiogenic effects of COX-2 over-expression [114,117,118] (Table S1).