The tumor-suppressing activity of necroptosis has been shown in many types of cancer in which the expression of RIPK3 [118,119] or MLKL [120] is silenced by methylation [18,34,121] or altered by polymorphisms in coding genes [118,122], suggesting that cancer cells evading apoptosis may also escape from necroptosis [13,18]. This evidence concerns the gene MLKL and cancer.