We previously showed that a JmjC-type KDM, KDM2A, decreases the dimethylated lysine 36 of histone H3 (H3K36me2) but not trimethylated lysine 36 of H3 (H3K36me3) in the rRNA gene (rDNA) promoter, and represses rRNA transcription under starvation in breast cancer cells [12,13]. Here, KDM2A is linked to breast carcinoma.