CREB3L4 and breast cancer: Adnan et al. also highlighted that the regulators of the cell cycle, including cyclin B1, cyclin B2, and CDK1, and estrogen-dependent BC signaling pathways (including MRAS, PIK3C2G, AKT3, CREB3L4, CREB5, and EGFR) are some of the most important canonical pathways predicted by ingenuity PA in Saudi BC samples [18].