Hereditary melanoma risk was not increased in carriers of low-risk gene mutations (Table 4); however, we found a higher frequency in patients vs. controls for mutations in TYRP1 (0.8 vs. 0%; p = 0.02) and OCA2 (2.3 vs. 0.5%; OR = 4.3; 95%CI 1.2–14.2; p = 0.01); Supplementary Table S4. This evidence concerns the gene OCA2 and melanoma.