In particular, the CM for CD8+ cell density within the IZ (CD8+ Immunogradient) was a strong independent predictor of better OS in CRC patients (HR: 0.39, p = 0.0071) [33], similar to that in the current analysis of an independent CRC cohort (HR: 0.31, p = 0.0029, Table 4). Here, CD8A is linked to colorectal carcinoma.