Recently, Rasmusson et al. proposed a set of Immunogradient indicators which quantifies the immune cell density gradient across the tumor-stroma interface zone (IZ), sampled by an automated hexagonal tiling statistical modeling; the Immunogradient indicators for CD8+ cell density provided independent prognostic value in CRC and hormone receptor positive breast cancer patients [33]. This evidence concerns the gene CD8A and colorectal carcinoma.