In obesity, systematic oxidative stress can also be induced by oxidative phosphorylation in mitochondria, superoxide generation from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), uncoupled endothelial nitric oxide synthase (eNOS) [13] and reduced antioxidant defense [8,14]. Here, NOS3 is linked to obesity due to melanocortin 4 receptor deficiency.