TNF and cardiovascular disorder: The primary adipokines that play a role in inflammation, metabolic and cardiovascular diseases include adiponectin, leptin, resistin, visfatin, tumor necrosis factor alpha (TNF-α), interleukin-6(IL-6), plasminogen activator inhibitor-1 (PAI-1), and vascular endothelial growth factor (VEGF) [66,67].