In this review, we summarize current knowledge on circadian rhythm, adipose tissue function, ROS production and oxidative stress in metabolic and cardiovascular diseases; dissect the key components that play a dual role in regulating the clock rhythm, as well as adipose tissue metabolism, and link adipose circadian rhythms with oxidative stress; and discuss the potential antioxidant treatment of metabolic and cardiovascular diseases by targeting circadian clock in adipose tissue. Here, CLOCK is linked to cardiovascular disorder.