CD274 and glioma: Rajaraman et al., showed that a sequential triple combination of TMZ or lomustine, oncolytic MV, and radiation therapy had a synergistic antitumor effect in glioma or stem-like glioma cell lines and identified a treatment-induced molecular and immunological signature [136], including an increase in chemokines regulating the immune response, an increase in the antigen presentation machinery, and in PD-L1 transcription.