Mesenchymal-like NSCLC cells evince aberrant PDGFR and FGFR expression and autocrine signalling through these receptors can activate the MEK-ERK and PI3K pathways.Another GPCR family member, GPR171, identified as a potential tumour-promoting gene, is also overexpressed in lung cancer [17]. Here, GPR171 is linked to lung carcinoma.