MBTPS1 and cancer: Recently, the role of the SKs/S1P/S1P-receptor pathway in the development of gastrointestinal pathologies and cancer has been extensively reviewed by Sukocheva et al. [2], who especially focused on its participation to the development and progression of gastrointestinal pathologies, like inflammatory bowel diseases (IBDs) and cancers of the digestive tract, characterized by an underlying flogistic processes.