In some cases, reverse phenotyping allowed the investigation and prevention of important comorbidities, as in P25, who carries a de novo partial duplication of the DMD gene, which in females could manifest with muscle weakness and cardiomyopathy, and in P20, who carries a 16p11.2 duplication widely reported in ASD studies which is associated with the risk of developing psychotic symptoms [91]. The gene discussed is DMD; the disease is cardiomyopathy.