Three phenotypical distinct CAF populations, FSP-1+α-SMA−, FSP-1+α-SMA+ or FSP-1−α-SMA+ ones were totally increased in bone marrow of MM patients at diagnosis and relapse than that of MM patients in remission or patients with monoclonal gammopathy of undetermined significance [107]. This evidence concerns the gene ACTA1 and Miyoshi myopathy.