LRP1 and familial pancreatic carcinoma: CAFs in pancreatic cancer form annexin A6/LDL receptor-related protein 1/thrombospondin 1 (ANXA6/LRP1/TSP1) complex, which is released in the form of extracellular vesicles (EVs), thereby enhancing the migratory capacity of cancer cells, which ingests EVs [84].