Simultaneously, cancer cells activate osteoblasts by releasing parathyroid hormone-like protein (PTHrP), Wnt-1, insulin-like growth factor (IGF)-1, and BMPs and/or using Jag1/Notch pathway, and activated osteoblasts further enhance osteoclast generation and activation by releasing RANKL [50,51]. The gene discussed is TNFSF11; the disease is cancer.