Interestingly, PTPN12 acts as a tumor suppressor which regulates the activities of multiple oncogenic tyrosine kinases, including EGFR, human epidermal growth factor receptor 2 (HER2), and platelet-derived growth factor receptor-β (PDGFRβ), and its deficiency is identified in several carcinomas [13,14]. This evidence concerns the gene ERBB2 and carcinoma.