Thus, patients with preexisting atherosclerotic lesions and chronic inflammation, then infected with COVID-19, may be at higher risk of disease severity, clinical complications such as acute coronary syndrome (ACS), and mortality, and may present conduction abnormalities, atrial fibrillation, hypotension, left ventricular dysfunction, and elevation in brain natriuretic peptide (BNP) and cardiac troponins [11,12,13]. The gene discussed is NPPB; the disease is COVID-19.