COVID infection may evoke a marked immune response and “inflammatory storm” (cytokine release syndrome-CRS, with an elevation of different cytokine levels, including interleukin IL-6, -7, -22, -17, chemokine ligand 2, and tumor necrosis factor α, TNFα), found associated with disease severity and mortality [9,10]. The gene discussed is TNF; the disease is congenital rubella syndrome.