MAPT and Alzheimer disease: Oxidative stress is identified as a primary event in AD pathophysiology and is related to deposition of Aβ plaques, which is further associated with cellular events, like p38 mitogen-activated protein kinase (MAPK) signaling activation, which causes the hyperphosphorylation of tau protein, resulting in the intracellular formation of neurofibrillary tangles (NFTs) and the B-cell lymphoma-2 (Bcl-2)-mediated induction of apoptosis resulting in the mitochondrial release of cytochrome C, as well as T cell infiltration into the neuronal parenchymal cells [44].