Very interesting results were obtained from Peinado and coworkers who identified a melanoma-specific exosomal signature in blood from patients with stage IV melanoma that included expression of tyrosinase-related protein-2 (TYRP-2), very late antigen-4 (VLA-4), HSP70, HSP90 and mesenchymal epithelial transition (MET) oncoprotein [128]. Here, DCT is linked to melanoma.