MiR-21, one of the most frequently up-regulated miRs in solid tumors, controls important tumor suppressor genes as well as genes involved in carcinogenesis, such as phosphatase and tensin homolog (PTEN), programmed cell death protein 4 (PDCD4), phosphoinositide 3-kinase (PI3K), Sprouty and reversion inducing cysteine rich protein with Kazal motifs (RECK) [114,115,116,117,118]. Here, PTEN is linked to neoplasm.