NF-κB has been proposed as being upregulated in conditions related to cancer onset and although rarely mutated itself, it plays a central role in a signaling network containing frequently mutated upstream molecules like RAS, EGFR or HER2, resulting in elevated NF-κB signaling and in cross-talk with genes related to ROS production, as well as the p53 pathway and the STAT pathway [128]. The gene discussed is NFKB1; the disease is cancer.