AXL, a receptor tyrosine kinase belonging with its homologs Tyro3 and Mer in the TAM (Tyro3-AXL-Mer) receptor kinase subfamily, is involved in epithelial-to-mesenchymal transition in adult GBM and has now been identified as a novel therapeutic target in diffuse intrinsic pontine glioma, correlating with HIST1H3B mutation. Here, TYRO3 is linked to diffuse intrinsic pontine glioma.