NMD such as Charcot-Marie-Tooth neuropathy type 2A (CMT2A) [74] or amyotrophic lateral sclerosis (ALS) can also be caused by mitochondrial mutations (CMT2A can be caused by mutations in MFN2 and ALS by mutations in SOD1) [59]. This evidence concerns the gene MFN2 and Charcot-Marie-Tooth disease type 2A1.