The findings of a recent study also demonstrated that the expression of GKN1 could be significantly downregulated in human gastritis and gastric cancer cells by H. pylori infection compared to H. pylori-negative gastritis cells, suggesting that its downregulation is mediated by the activation of the CagA-induced ERK pathway and AUF1 upregulation during H. pylori infection [107]. This evidence concerns the gene GKN1 and gastric cancer.