S100A8 and gastric cancer: A recent meta-analysis found a 1.91-fold increased risk for gastric cancer development associated with the presence of a single EPIYA-D sequence (EPIYA-A, -B, -D) in Asian countries compared with the presence of a single EPIYA-C sequence (EPIYA-A, -B, -C), and the presence of CagA with two or more EPIYA-C sequences (EPIYA-A, -B, -C, -C or EPIYA-A, -B, -C, -C, -C) was associated with a significant increase in the risk for PUD in Asian countries, while a 3.28-fold increased risk was observed for gastric cancer in the USA and Europe [28].