GKN1 inhibits the invasion and metastasis of gastric cancer cells, and the downregulated expression of GKN1 has been related to the poorer prognosis of intestinal gastric cancer, which has been demonstrated in chronic gastritis and gastric cancer tissues infected with H. pylori, suggesting that H. pylori-positive gastritis might progress to gastric cancer [103,104,105,106]. This evidence concerns the gene GKN1 and gastric cancer.