S100A8 and gastric cancer: Several H. pylori virulence factors that have been estimated to contribute to the pathogenicity and development of gastric cancer are vacuolating cytotoxin A (VacA) (Reviewed by Ansari and Yamaoka [12]), cytotoxin-associated gene pathogenicity island (cagPAI), an oncoprotein (i.e., cytotoxin-associated gene A (CagA)), and adhesion proteins [13].