CARTs were employed to deliver mRNA for CD70, OX40L, CD80, and CD86 (co-stimulatory proteins for T-cells), as well as IL-12 and IFN-γ (cytokines that enhance Th1 tumoricidal response) to macrophages in murine subcutaneous models of two tumors, where only one tumor was treated. Here, CD80 is linked to neoplasm.