Cancer cells killed by ICD expose calreticulin and other endoplasmic reticulum proteins; they release cytokines and damage-associated molecular patterns (DAMPs), such as ATP or HMGB1, and also tumor antigens, which stimulate antitumor immune responses, resulting in the recruitment and activation of macrophages and T cells to fight against the cancer cells. The gene discussed is HMGB1; the disease is cancer.