They are implicated in the initiation and progression of the tumor, through the secretion of signaling molecules, such as transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), macrophage colony-stimulating factor (M-CSF), interleukins or chemokines (IL-10, IL-6, and CXCL-8) [19,20,21], and extracellular vesicles (EV) with immunosuppressive properties [22]. Here, VEGFA is linked to neoplasm.