In several tumor types, such as osteosarcoma and esophageal tumors, their presence is associated with better overall survival and longer metastasis progression-free survival [12,13]; instead, in other tumors, macrophages are associated with worse prognosis, especially when linked to low numbers of CD8+ cells, the lymphoid cellular type responsible for the killing of tumor cells [14,15,16,17]. The gene discussed is CD8A; the disease is neoplasm.