IL4 and breast carcinoma: IL-4 induces the protease activity of cathepsins that promotes breast cancer invasion and metastasis [24]; other factors secreted by TAMs, such as TGF-β, VEGF, CCL8, COX-2, SPARC, MMP9, and MMP2 contribute to the metastatic properties of cancer cells [25,26,27,28,29,30].