In CF mouse nasal epithelial cells, the levels of glutathione S-transferase (GST), which catalyzes the glutathione-mediated detoxification of oxidative stress products, peroxiredoxin 6 (Prdx6), a glutathione-dependent peroxidase (Gpx) involved in defense against oxidative stress, and Hsp27, a heat shock protein that increases intracellular levels of glutathione and acts as a chaperone for detoxification, were all reduced. Here, HPGDS is linked to cystic fibrosis.