AARS1 and Charcot-Marie-Tooth disease: Fly models of CMT caused by mutations in aaRS encoding genes reproduced the clinical phenotypes of CMT patients, such as an impaired motor function, axonal degeneration, muscle denervation and synaptic dysfunction [51,98,99,100,101]; however, notably, the development of motor symptoms did not depend on the enzymatic activity of aaRS in these models.