Among many genes in which mutations are reported to cause CMT2, research on the following important genes and their functions has markedly progressed using Drosophila models: MFN2, Ganglioside Induced Differentiation Associated Protein 1 (GDAP1), RAB7A, Member RAS Oncogene Family (RAB7), Glycyl-tRNA Synthetase (GARS), Alanyl-tRNA Synthetase (AARS), Methionyl-tRNA Synthetase (MARS), Histidyl-tRNA synthetase (HARS), and Sorbitol dehydrogenase (SORD). This evidence concerns the gene MARS1 and Charcot-Marie-Tooth disease type 2.