For instance, blockade of 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3 (PFKFB3), a key regulator of glycolysis in ECs, normalizes tumor vessels with increased pericytes coverages and enhances EC barrier function through decreased VE-cadherin endocytosis [7]. Here, PFKFB3 is linked to neoplasm.