Although Ldlr−/− mice typically do not develop substantial atherosclerosis on a low-fat diet [12], we observed modestly but significantly elevated lesion formation in the thoracic aorta of 16-week-old normal chow-fed Ldlr−/−LmnaG609G/G609G mice (Figure S2a), and this was independent of serum cholesterol level (Figure S2b). Here, LDLR is linked to atherosclerosis.