Although Ldlr−/−LmnaG609G/G609G mice had a lower plaque area than Ldlr−/−Lmna+/+ controls, they had a higher percentage of the aortic perimeter affected by atherosclerosis, an effect that was more pronounced in males and in aortic root sections more distal from the heart (Figure 2b for males; Figure A2b for females and Figure S3). The gene discussed is LDLR; the disease is atherosclerosis.