Moreover, both Ldlr−/−LmnaG609G/G609G and Apoe−/−LmnaG609G/G609G models showed key hallmarks of HGPS-associated vascular disease, including augmented atherosclerosis, smooth muscle cell loss in the media, and adventitial thickening. The gene discussed is LDLR; the disease is Hutchinson-Gilford progeria syndrome.