To generate a new mouse model to study atherosclerosis in HGPS, we crossed atheroprone Ldlr−/− mice with progeroid LmnaG609G mice, which carry a c.1827C>T; p.G609G mutation in the Lmna gene and, like HGPS patients, produce progerin through aberrant splicing [14,16]. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.