LMNA and Hutchinson-Gilford progeria syndrome: HGPS patients are heterozygous for the LMNA mutation; however, LmnaG609G mice seem to be more resistant to progerin-induced damage [14], and all further studies were performed with homozygous Ldlr−/−LmnaG609G/G609G mice because their phenotype is more severe and more similar to that seen in human patients.