This is in accordance with our results, where high rates of TGAACA mutations were significantly associated with high expression levels of APOBEC3B in our bladder tumor samples, but not with those of the APOBEC3A. The interrogation and interpretation of non-coding mutations in cancers will become more accurate with the increasing availability of whole-genome sequencing data. The gene discussed is APOBEC3B; the disease is urinary bladder neoplasm.