In order to assess the specificity of the non-coding mutations identified in our 103 bladder cancer series, we checked whether the five most frequently mutated non-coding sites (i.e., GPR126, PLEKHS1, Intron ADM, Chr7:11, and Chr15:96) were present in different series of 51 prostate tumors, 10 colorectal tumors with high microsatellite instability (MSI-H), and 10 human papilloma virus (HPV)-positive Head and Neck Squamous Cell Carcinoma (HNSCC). The gene discussed is PLEKHS1; the disease is head and neck squamous cell carcinoma.