To test a possible common molecular mechanism of tumor genomic instability that could explain these high frequencies of palindromic non-coding somatic mutations at the core motif (TGAACA) specifically observed in bladder cancer, we sought positive associations between the five most frequently mutated non-coding sites (i.e., GPR126, PLEKHS1, Intron ADM, Chr7:11, and Chr15:96). This evidence concerns the gene PLEKHS1 and neoplasm.