Moreover, the expression level of individual genes in this panel, including GBP5, IL7R, PNMA2, ITGA3, COL16A1, FCGR1A, MEP1A, CTSV, FAM183A and PLAC8, were strongly associated with distant metastasis, lymph node metastasis, tumor stage, clinical stage, or pathologic grade. The gene discussed is CTSV; the disease is metastatic malignant neoplasm in the lymph nodes.