Analysis of the relationships between the above genes in DEG panel and HCC clinicopathological features revealed that GBP5, IL7R, PNMA2, ITGA3, COL16A1, FCGR1A, MEP1A, CTSV, FAM183A and PLAC8 expression were strongly linked to distant metastasis, lymph node metastasis, T stage, clinical stage or pathologic grade (Figure 6H, Supplementary Figure 1B). The gene discussed is PLAC8; the disease is hepatocellular carcinoma.