CALCA and metastatic malignant neoplasm in the lymph nodes: Univariate analysis reported that male gender (p< 0.0001), age < 45 years (p= 0.011), and preoperative calcitonin level > 65 pg/ mL (p< 0.0001), nodule Ø > 5 mm (p< 0.0001), and multifocality of nodules (p< 0.0001) were associated with lymph node metastasis (Table 4).