GJA1 and hypertrophy: Indeed, reductions in the expression and heterogeneous redistribution of GJA1 have been reported in decompensated human hypertrophy [35], arrhythmogenic cardiomyopathy [36], ischemic samples [35], and induced -pluripotent stem cell (iPS)-derived cardiomyocytes from patients with cardiomyopathy [37].