CAT and intestinal neoplasm: Intriguingly, HH and WNT/β-cat pathways are known to induce immune exclusion: HH suppresses T cell recruitment by inhibiting CXCL9 and CXCL10 production (CXCL10 was indeed significantly downregulated in K/P WT intestinal tumors), and WNT/β-cat activation has been correlated with refractoriness to immune checkpoint blockers (31–33, 54–56).