The results revealed that (Table 2) patients with III‐IV stage, Breslow's thickness ≥1.5 mm, LNM and distant metastasis had an increased ratio of high HDAC3 expression and low miR‐495‐3p expression (all P < .05), indicating that the expression of HDAC3 and miR‐495‐3p was related to TNM stage, Breslow's thickness, LNM and distant metastasis of patients (all P < .05), while was not correlated to age, gender, tumour classification and anabrosis (all P >.05). The gene discussed is HDAC3; the disease is neoplasm.