INS and hypothyroidism: As opposed to other experimental models of hypothyroidism (Hine et al., 2017; Umezu et al., 2020), we found that the PAX8 heterozygous mice faithfully recapitulate the phenotype of humans with hypothyroidism, including insulin resistance, increased white adipose tissue (WAT) mass, and increased triglyceride content in skeletal muscle and liver (Lopez‐Noriega et al., 2019).