Moreover, separated evidences indicate that differences in deiodinase expression and differential splicing have been found in several cancers (Meyer et al., 2008) and increased TSHR expression have been detected in liver, ovarian, lung, and breast cancers (Table 1) (Govindaraj et al., 2012; Gyftaki et al., 2014; Kim et al., 2012; Shih et al., 2018; Tian et al., 2010). Here, TSHR is linked to cancer.