Studies have shown that in lung cancer, after aberrant splicing, the expression of BCL2L1, MDM2, MDM4, NUMB, and MET may play an important role in tumorigenesis, which may be due to the effects on cell apoptosis, cell proliferation, and intercellular cohesion‐related pathways.18, 19, 20. This evidence concerns the gene NUMB and lung cancer.