(A) Domains of PRDM9 and HELLS PRDM9 includes a Krüppel-associated box domain (KRAB), a synovial sarcoma-X break point-repression domain (SSXRD), a Su(var)3–9, Polycomb-group protein enhancer of zeste and trithorax-group protein TRX domain (PR/SET) that is preceded and followed by zinc-finger domains (ZK and ZF, respectively), and a C2H2-type zinc-finger array (C2H2 ZF array). Here, SET is linked to synovial sarcoma.