Besides IL‐6, other cytokine signaling components including IL‐8, TNF‐R, sIL‐2R, and M‐CSF have been shown to correlate with tumor grade and size in STS patients, and the serum levels of some of these proteins were associated with the prognosis (Rutkowski et al, 2003). The gene discussed is CXCL8; the disease is neoplasm.