CD8A and neoplasm: For example, OS tumor tissues are infiltrated by T lymphocytes (tumor‐infiltrating lymphocytes, TILs) in a very high percentage of patients, mainly expressing CD8+ (Théoleyre et al, 2005; Palmerini et al, 2017), and both TILs and tumor cells showed a high expression of HLA‐DR compared with other, non‐malignant bone tumors (Trieb et al, 1998).