Here, the authors showed that common sarcomas (except for SS) are characterized by a high number of copy‐number variations (CNVs) and recurrent point mutations in relatively few genes, such as TP53, ATRX, and RB1. Importantly, specific genomic and transcriptomic alterations also define molecular subtypes, which are associated with patient outcome (Cancer Genome Atlas Research Network, 2017). Here, ATRX is linked to synovial sarcoma.