In contrast to OS and most sarcomas of adulthood, translocation‐driven pediatric sarcomas, such as EwS, SS, or fusion‐positive ARMS, exhibit much lower rates of single‐nucleotide variants and CNVs, and, instead, appear to be driven by marked epigenetic and transcriptomic perturbations induced by the fusion oncoproteins (Shern et al, 2014; Tirode et al, 2014; Cancer Genome Atlas Research Network, 2017). The gene discussed is EWSR1; the disease is sarcoma.