Increased serum levels of cytokines and their soluble receptors that are involved in bone degradation (e.g., IL‐6 and IL‐8) and bone formation (e.g., tumor necrosis factor receptor I [TNFRI]) are positively correlated with tumor size and local tumor extent, which is associated with worse overall survival in adult bone sarcoma patients (Rutkowski et al, 2003). Here, TNFRSF1A is linked to neoplasm.