Moreover, MSCs/CAFs regulate tumor growth and metastasis through PDGFRα/β and MIF‐CXCR4/7 signaling, enhancing sarcoma aggressiveness via the secretion of inflammatory cytokines, exosomes (Miller et al, 2013; Cortini et al, 2016; Avnet et al, 2017; Baglio et al, 2017; preprint: Evdokimova et al, 2019), or metabolites that can fuel the oxidative metabolism of tumor cells (Bonuccelli et al, 2014). Here, CXCR4 is linked to sarcoma.