Consistently, cancers with high UPK1A gene amplification frequency exhibited high expression of UPK1A in lung squamous cell carcinoma, lung adenocarcinoma, uterine corpus endometrial carcinoma, pancreatic adenocarcinoma, which indicates UPK1A gene amplification may account for upregulation of UPK1A in these cancers. The gene discussed is UPK1A; the disease is cancer.