CXCR4 and central nervous system cancer: Figure 6 showed that differentially regulated genes were mainly enriched in the canonical pathways of glioma invasiveness signaling, IL-8 signaling, molecular mechanisms of cancer, CXCR4 signaling and et al. It was noted that IL-8 signaling was significantly suppressed in shPRIM1 group, with z-score of -2.200 and -2.132 respectively.