A high level of IL-33 in breast cancer tissues was correlated with lymph node involvement and metastasis 15; and a high level of IL-33 in tissues revealed short survival in colorectal cancer 24, ovarian cancer 27, glioblastoma 29, renal cell carcinoma 30 and hepatocellular carcinoma 25. The gene discussed is IL33; the disease is hepatocellular carcinoma.