A high level of IL-33 in cancer was observed in this study at approximately 53% in CCA tissues compared to 38% reported in colorectal cancer 24, 41% in hepatocellular carcinoma 25, 59% - 67% in ovarian cancer 26, 27 and 56% in non-small cell lung cancer 28. This evidence concerns the gene IL33 and hepatocellular carcinoma.