CEACAM5 and neoplasm: Tumor downstage predictive factors included older age (OR=1.031, 95% CI: 1.008-1.054, P=0.007), cTNM stage III (OR=4.405, 95% CI: 2.150-9.025, P<0.001), G1/2 tumor differentiation (OR=2.757, 95% CI: 1.238-6.137, P=0.013) and lower CEA ratio (OR=0.393, 95% CI: 0.187-0.829, P=0.014).