The aim of this study was to evaluate the prognostic differences among T stages (T1, T2, T3a, T3b-4) and PSA levels (PSA <4.0 ng/ml, 4.0-10.0 ng/ml, 10.1-20.0 ng/ml, 20.1-40.0 ng/ml, >40 ng/ml) in patients with non-metastatic high grade (T1-4N0M0 GS 8-10) PCa. Here, KLK3 is linked to posterior cortical atrophy.