With PSA < 4.0 ng/ml as the reference, the HR of PSA 4.0-10.0 ng/ml, PSA 10.1-20.0 ng/ml, and PSA >20.0 ng/ml for cancer-specific mortality of men with high-grade PCa were 0.79 (0.69~0.9), 1.09 (0.95~1.25) and 1.84 (1.61~2.1), respectively. Here, KLK3 is linked to posterior cortical atrophy.