To test whether PPZ023 suppresses the growth of human NSCLC cell lines, H460 and A549 cells, as well as human normal lung cells, MRC5 cells, were treated with PPZ023 at different concentrations for 24 h, and cell viability, LDH cytotoxicity, and caspase-3 activity were analyzed. This evidence concerns the gene CASP3 and non-small cell lung carcinoma.