MED12 and neoplasm: The discovery of highly recurrent Mediator complex subunit 12 (MED12) somatic mutations in breast FA was surprising; almost nothing had previously been known about these mutations.22 As for PT, in addition to MED12,10–13,23–27 the telomerase reverse transcriptase (TERT) promoter has been shown to have repeated mutations in these tumours.28–34