Other noteworthy genes include cysteine-rich secretory protein 3 (CRISP3), which has also been linked to the development of PE, asthma, and weight gain41–43 and metalloproteinase-8 (MMP8) which has been reported in association with pre and in-pregnancy excess BMI, PE, and asthma as well46,47,4445. The gene discussed is MMP8; the disease is asthma.