ARHGAP15 and premenstrual tension: Interestingly, Capitan et al.12 also reported a novel developmental disorder involving polledness—the Polled and Multisystemic syndrome (PMS)—in cattle which was associated with loss of heterozygosity of a very large (~ 3.7 Mb) genetic segment involving ARHGAP15, GTDC1 and ZEB2 genes.