Understanding the mechanisms whereby CD4+ and CD8+ T cell, and B cell restricted epitopes are associated with protection of HLA-A*11:01, HLA-A*02:01, and HLA-B*07:02 mice against toxoplasmosis, underline the role of the ToxAll scaffold in the rational design of a T cell- epitope based vaccine strategy. The gene discussed is HLA-B; the disease is toxoplasmosis.