Significant differences in both HER2 and VEGFR immunoreactivity intensities between the control untreated tissues (Fig. 6d,g) and 5-FU and 5-FU-SLN4 treated tumor (p < 0.0001 and p < 0.001 respectively, Table 3) were observed when the stained sections were further analyzed as shown in Table 3. Here, ERBB2 is linked to neoplasm.